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Aceclofenac is a common prescribed anti-inflammatory and nonsteroidal drug that is used the manage inflammation and pain. This medicine belongs to the same class as diclofenac and ibuprofen, but the more favourable and safe profile of aceclofenac make the medicine a preferred choice for chronic conditions and long-term treatments. Now, in this blog, let us get to know more about aceclofenac uses, side effects, dosage and precautions.

What is Aceclofenac?

Aceclofenac is basically an NSAID that is primarily used to bring down pain, swelling, and inflammation. This has an action by inhibiting the enzyme "Cyclooxygenase (COX)" in the body. When an injury occurs, this enzyme causes the release of prostaglandins, which are chemical messengers that cause inflammation, pain, and swelling. Aceclofenac is an anti-inflammatory and pain reliever that works by inhibiting the COX enzyme.

Uses of Aceclofenac

Aceclofenac is effective in treating a variety of conditions, particularly those related to pain and inflammation. Here are the primary conditions for which it is prescribed:

• Osteoarthritis: Aceclofenac is commonly used to relieve joint pain, stiffness, and inflammation associated with osteoarthritis, especially in the knees and hips.
• Rheumatoid Arthritis: Inflammation in the joints caused by rheumatoid arthritis can be managed effectively with Aceclofenac.
• Ankylosing Spondylitis: Aceclofenac can help manage the chronic pain and stiffness in the spine caused by this condition.
• Lower Back Pain: For many individuals suffering from chronic or acute lower back pain, Aceclofenac offers relief by reducing inflammation and discomfort.
• Dental and Post-Surgical Pain: Dentists often recommend Aceclofenac to manage pain following tooth extraction or other dental procedures. It’s also prescribed for post-operative pain management in other surgical contexts.

Dosage of Aceclofenac

The dosage of Aceclofenac depends on the condition being treated, as well as the patient’s age, health status, and severity of symptoms.

Common Dosage:

• For adults: The usual dose is 100 mg twice daily (one tablet in the morning and one in the evening).
• For elderly patients: The same 100 mg twice daily dose is often prescribed, but dosage adjustments may be necessary based on overall health and kidney function.

Aceclofenac should be taken with or after meals to minimize gastrointestinal irritation. It’s essential to follow the prescribed dosage and not exceed it without consulting a healthcare provider.

Side Effects of Aceclofenac

Like all medications, Aceclofenac may cause side effects, although not everyone experiences them. Some common and more severe side effects include:

Common Side Effects:

• Gastrointestinal issues: Nausea, indigestion, diarrhea, and stomach pain are frequent complaints.
• Headache: A mild to moderate headache is possible, especially when starting the medication.
• Dizziness or drowsiness: Some individuals may experience dizziness or feel unusually tired.

Serious Side Effects

• Gastrointestinal bleeding or ulcers: Long-term use can irritate the stomach lining, leading to bleeding, ulcers, or perforations.
• Heart problems: Prolonged use of Aceclofenac, particularly at high doses, can increase the risk of heart attacks or strokes, particularly in individuals with existing cardiovascular conditions.
• Liver and kidney damage: In rare cases, Aceclofenac can impair liver or kidney function, leading to abnormal blood tests or more severe symptoms such as jaundice (yellowing of the skin or eyes).

If you experience symptoms such as persistent stomach pain, black or bloody stools, unexplained weight loss, chest pain, or difficulty breathing, seek medical attention immediately.

Precautions and Contraindications

Before taking Aceclofenac, certain precautions should be considered to ensure safe usage.

Precautions:

• Gastrointestinal risks: Patients with a history of ulcers, Crohn's disease, or inflammatory bowel disease should use Aceclofenac cautiously as it may worsen these conditions.
• Heart disease and stroke: Individuals with a history of heart disease, high blood pressure, or stroke should inform their doctor as NSAIDs can increase the risk of cardiovascular events.
• Kidney or liver impairment: Aceclofenac is processed by the liver and excreted through the kidneys. If you have pre-existing liver or kidney conditions, your doctor may adjust the dosage or recommend regular blood tests to monitor your organ function.
• Pregnancy and breast-feeding: Aceclofenac is generally not recommended during pregnancy, especially during the third trimester, as it can affect fetal development. Breastfeeding mothers should also consult their healthcare provider before taking the drug.
• Elderly patients: Seniors are more prone to the side effects of NSAIDs, particularly gastrointestinal issues and kidney impairment. Special caution and close monitoring are advised.

Drug Interactions:

Aceclofenac can interact with other medications, which may reduce its effectiveness or increase the risk of side effects. Key interactions include:

• Anticoagulants (e.g., warfarin): Aceclofenac may increase the risk of bleeding.
• Diuretics: NSAIDs can reduce the effectiveness of diuretics and increase the risk of kidney damage.
• Lithium or methotrexate: These drugs can become more toxic when combined with Aceclofenac due to reduced clearance from the body.
• Other NSAIDs or corticosteroids: Combining Aceclofenac with other anti-inflammatory drugs increases the risk of gastrointestinal side effects and ulcers.

Always inform your healthcare provider about any medications or supplements you are taking to avoid harmful interactions.

Who Should Avoid Aceclofenac?

Certain groups of people should avoid using Aceclofenac or consult their doctor for alternative treatments. These include:

• People with a history of allergic reactions to other NSAIDs like ibuprofen or aspirin.
• Patients with severe heart, liver, or kidney disease, as Aceclofenac can worsen these conditions.
• Pregnant women, particularly during the third trimester, should avoid Aceclofenac to prevent potential harm to the unborn child.
• Children and adolescents: Aceclofenac is generally not recommended for children unless specifically advised by a healthcare provider.

Conclusion

Aceclofenac is a potent NSAID used to manage pain and inflammation in conditions like arthritis, back pain, and post-surgical discomfort. While it is highly effective, it’s essential to follow the recommended dosage and be mindful of potential side effects, especially when used over long periods. Regular consultation with your healthcare provider is key to ensuring safe and effective treatment with Aceclofenac.

If you have any concerns about using Aceclofenac, consult your doctor or pharmacist for personalized advice.